Thematic Research Area: Biomaterials and Tissue Engineering

 

Integrative Tissue Engineering Laboratory : The focus of the Integrative tissue engineering laboratory is to decipher the underlying mechanism of tissue repair and regeneration over a length scale of ‘micro to nano’, and to translate the understanding into bioengineering strategies for tissue engineering and regenerative medicine. Precisely, we are keen to address three fundamental questions. Firstly, what are the novel clues (universal or cell specific) that contributes significantly to the physiological processes related to tissue repair and regeneration; secondly, how these different cues / factors co-exist, modulate and cooperate in tissue repair and regeneration and finally, up to what certainty such factors can be manipulated spatio-temporally to engineer the outcome of tissue engineering and regenerative medicine. In pursuance of the goal, we have adopted a trans-disciplinary approach that involves strategic amalgamation of the knowledge and techniques of cell biology, regenerative biology, biomaterial science, microfluidics, nanotechnology and tissue engineering. The benefit of such approach is that it is comprehensive and integrative in nature like any complex physiological process. We believe that the integrative approach will help us to gain a deep insight and comprehensive understanding of tissue repair and regeneration. Furthermore, such approach will make tissue engineering an affordable, reproducible and safe health care technology in near future for on-demand production of the so called spare parts of human body.

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In line with the goal, we are now deducing the following problems

(i) Deciphering the mechanism of angiogenesis and tuning of the biomaterial mediated angiogenic response

(ii) Mechanistic analysis of osteogenic differentiation and biomaterial induced osteogenesis

(iii) Reconstruction of cell-friendly 3D micro-architecture with reproducible design parameters for bone tissue engineering.

(iv) Synthesis and characterization of cell derived membrane vesicles and understanding of its regenerative potential.

(v) Development of organ –on –chip to probe the cellular cross talk.